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Preventing Diabetic Foot Ulcers: The Importance of Vitamin D Screening and Supplementation

Introduction: The Menace of Diabetic Foot Ulcer (DFU)

Diabetic Foot Ulcer (DFU) presents a formidable threat to diabetic patients, encompassing limb amputation, increased mortality, economic burden, and a diminished quality of life. Its prolonged healing process adversely impacts health, job, income, and healthcare.

Exploring the Link: DFU and Vitamin D Deficiency

Evident in diabetic patients, DFU demonstrates a concerning association with vitamin D deficiency. Vitamin D plays a crucial role in immune response, insulin secretion, and sensitivity, prompting the need for further investigation into its impact on DFU outcomes.

recent studies have found the connection between vitamin D and diabetic foot ulcers

A meta-analysis of four studies, encompassing 197 participants, sheds light on the impact of vitamin D supplementation on DFU outcomes. Significant differences in various parameters, including ulcer area and serum vitamin D, underscore the potential benefits of such interventions. The prevalence of vitamin D deficiency was observed more in individuals with a diabetic foot ulcer in contrast to those without. (1)

Unraveling Mechanisms: Vitamin D's Role in Diabetic Complications

Research unveils that low serum vitamin D levels are intricately linked to insulin resistance, impaired β-cell function, and the development of diabetic complications. Zubair et al.'s findings emphasize the significant role of lower 25(OH)D in the pathogenesis of foot ulcers, involving multiple mechanisms. (2)(4)

Vitamin D's Reach: The Extensive Vitamin D Receptor (VDR)

Vitamin D, a steroid prohormone, exerts its effects through the widespread presence of the vitamin D receptor (VDR) in various tissues. This mechanism underscores the systemic impact of vitamin D on different aspects of health. (3)

Recent studies establish a direct association between low vitamin D levels and the severity of foot ulcers in older diabetic individuals. This revelation emphasizes the need for routine vitamin D screening through a simple blood test, guiding potential supplementation to lower the risk of foot ulcers.

DFU as a Burden: Economic and Health Implications

DFU, a severe complication of diabetes, imposes a substantial economic burden, with potential consequences such as diabetic foot osteomyelitis, increased mortality, decreased quality of life, and a heightened risk of lower limb amputation. (3)

Empowering Proactivity: Screening and Supplementation Recommendations

raise the awareness of the importance in vitamin D

Encouraging patients to undergo routine screening for vitamin D deficiency is paramount. This knowledge empowers individuals to take charge of their health, fostering a proactive approach to diabetes management and overall well-being.

In conclusion, understanding the intricate relationship between DFU and vitamin D levels is crucial for diabetic patient care. Routine screening for vitamin D deficiency may help to guide proactive measures, potentially preventing the severity of DFU and its associated complications. This knowledge empowers individuals to take charge of their health, fostering a proactive approach to diabetes management and overall well-being.


  1. Kinesya, E., Santoso, D., Gde Arya, N., Putri Cintya, E., Seriari Ambarini, P., Kinesya, B., Stephanie Kartjito, M., & Mannagalli, Y. (2023). Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clinical Nutrition ESPEN, 54, 137–143.

  2. Dai, J., Jiang, C., Chen, H., & Chai, Y. (2019). Vitamin D and diabetic foot ulcer: A systematic review and meta-analysis. Nutrition & Diabetes, 9(1).

  3. Tang, Y., Huang, Y., Luo, L., Xu, M., Deng, D., Fang, Z., Zhao, X., & Chen, M. (2023). Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and factor associated with diabetic foot ulcers. Diabetology & Metabolic Syndrome, 15(1).

  4. Zubair M, Malik A, Meerza D, Ahmad J. 25-Hydroxyvitamin D [25(OH)D] levels and diabetic foot ulcer: is there any relationship? Diabetes Metab. Syndr. Clin. Res. Rev. 2013;7:148–153. doi: 10.1016/j.dsx.2013.06.008.

This content is intended for educational purposes only and is not a substitute for professional medical advice. If you have any questions or concerns about your health, please consult with a healthcare professional.

[FREND System]

Rapid quantitative immunoassay analyzer

FREND is a quantitative immunoassay analyzing instrument that utilizes disposable cartridge to provide in vitro diagnostics results.

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