top of page
  • Writer's pictureNanoEntek

All about Vitamin D

Updated: Apr 24, 2023

The diefinition of vitamin D and the interpreation of the vitamin D level



What is vitamin D?

Vitamin D (also referred to as “calciferol”) is a fat soluble vitamin that is naturally present in a few foods, added to others, and available as dietary supplement.



How is it made?

It is also produced endogenously when ultraviolet (UV) rays from sunlight strike the skin and trigger vitamin D synthesis.


Vitamin D has two main forms, D2 (ergocalciferol) and D3 (cholecalciferol), that differ chemically only in their side-chain structures, Both forms are well absorbed in the small intestine.


The importance of vitamin D in a human body

The main role of vitamin D in human body is to regulate the calcium use to support the formation of the bones. The receptors in a small bowel enterocytes enhance calcium and phophosrus absorption, and bone receptors stimulate mineralization of newly formed bone.


Other fucntions of vitamin D

Function

Deficiency

Modulates immun system and pro-inflammatory cytokines = Reduction of inflammation

Arthritis, lupus, IBS, Multiple sclerosis

Inhibits cell growth / agniogenesis / differentiation

Cancer (prostate, breast, colon)

Glucose metabolism / pancreatic B-cell function / Insulin sensitivity

Diabetes mellitus

Influences smooth muscle tone, endothelium cardiomyocytes, controls intracelllar Ca+, RAAS

Cardiovascular disease, hypertension, stroke

Anti-oxidative / neuroprotective

Dementia, Alzhehimer's, schizophrenia, depression

The main role of vitamin D in human body is to regulate the calcium use to support the formation of the bones. The receptors in a small bowel enterocytes enhance calcium and phophosrus absorption, and bone receptors stimulate mineralization of newly formed bone.

Myofasial pain, Musuloskeletal pain, myopathy

What happens if vitamin D levle is too high or Low?

Vit D Deficiency

Vit D Excessive

Rickets

Calcification of soft tissue

Poor absorption

Renal failure

Short Bowel Syndrome

Antiepileptic treatment

Biliary cirrhosis (liver disorder)

Nephrotic syndrome

osteomalacia

Decreased 1,25-(OH) Vitamin D when PTH synthesis secrtion is impaired

Aging

Obesity

(Body mass index > 30 kg/square meter)

What is normal reference range for vitamin D?

There are several recommendations on the vitamin D deficiency

nmol/L

Vitamin D

Council

Endocine

Society

Food and Nutrition Board

Testing Laboratories

Deficient

(ng/mL)

0 - 30

0 - 20

0 - 11

0 - 31

Insufficient

(ng/mL)

31 - 39

21 - 29

12 - 20

Enough

(ng/mL)

40 - 80

30 - 100

> 20

32 - 100

Excessive

(ng/mL)

> 150

Reference


[FREND System]

Rapid quantitative immunoassay analyzer

FREND is a quantitative immunoassay analyzing instrument that utilizes disposable cartridge to provide in vitro diagnostics results.


[Related Items]




Recent Posts

See All

Comments


bottom of page