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About U2OS Cells

What are U2OS cells?

U2OS cells are one of the first and most commonly used cell lines, originating from a 15-year-old girl with osteosarcoma in 1964. These epithelial cells produced from bone are known as the first human cell lines from a mesenchymal tumors [1].


Characteristics of U2OS cells

Unlike normal cells, U2OS cells have a polyploid karyotype, a state where chromosomes are more than diploid (diploid : paired in two chromosomes).


Applications applied

U2OS cells, like other cell lines, are frequently used in cancer research since they are derived from bone cancer. As a result, they tend to be used to study the biological responses of osteosarcoma to therapies. They are also beneficial in drug development, apoptosis studies, and genetic study to further explore numerous fields in discovering therapies for many cancers [2].



Its particular characteristics make U2OS cells more adaptable in cancer research due to their stable luciferase expression, making them more useful for in vivo bioluminescence imaging to not only study cancer but also monitor treatment activity [1].


References:



 

Introducing NanoEntek latest automated cell counters


ADAM MC Plus
ADAM MC Plus

Cell types

Cell lines, primary cells

Measuring range

5x10E4 - 2x10E7 4x10E5 - 1x10E7 (optimal)

Loading volume

15 μL

Staining reagent

Acridine orange / DAPI


ADAM CellT Plus
ADAM CellT Plus

Cell types

Cell lines, primary cells

Measuring range

5x10E4 - 2x10E7 4x10E5 - 1x10E7 (optimal)

Loading volume

15 μL

Staining reagent

Acridine orange / DAPI

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Compliant

NanoEntek also provides a live cell imaging system


JuLI Stage
JuLI Stage

Objective lens

4x, 10x, 20x

Channel type

Brightfield, GFP, RFP, DAPI

Vessel type

Well plate, flask, dish, slide

Incubator installation

Available


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